After years of pursuit, Assistant D.A. Martin Ferguson has a good case against Murder, Inc. boss Albert Mendoza. Mendoza is in jail and his lieutenant Joseph Rico is going to testify. But Rico falls to his death and Ferguson must work through the night going over everything to build the case anew.

All the hot gamblers are in town, and they're all depending on Nathan Detroit to set up this week's incarnation of "The Oldest Established Permanent Floating Crap Game in New York"; the only problem is, he needs $1000 to get the place. Throw in Sarah Brown, who's short on sinners at the mission she runs; Sky Masterson, who accepts Nathan's $1000 bet that he can't get Sarah Brown to go with him to Havana; Miss Adelaide, who wants Nathan to marry her; Police Lieutenant Brannigan, who always seems...